But sure how that’s possible because the high is what relieves the pain for me. Not thinking about pain when I’m stoned off my ass.
We’d just have to try it and find out, I guess.
Surely couldn’t hurt, especially if it doesn’t affect your tolerance for THC. Cause I really need to take a tolerance break, but I need pain relief and sleep more.
What about CBD-based sleep aid gummies?
Unfortunately I’ve been there, done that. I feel nothing from CBD whatsoever. No pain relief, no appetite, no sleep. Feels like eating a snack
Nope, I need my THC, so it’ll be interesting to see how this discovery plays out. Maybe I can finally get the relief I need without worrying about needing t-breaks.
Yeah unfortunately I’m the same way. Have tried several CBD things and not one of them do anything for me unless I go max dose, and even then it’s an incredibly mild effect. THC takes nearly nothing though, 15mg is enough for a very strong high. I have friends where the complete opposite is true and I would love to trade them.
I would love to trade them.
Having a low tolerance is great for your wallet!
Oh it absolutely is, and I’ve got a low tolerance for alcohol too, which is pretty nice. I just wish that if I had to choose which of THC and CBD I had a low tolerance for, it’d be CBD.
Can I get the high without the pain relief? I don’t like risking overdose on too many marijuanas
That’s the second path of the production line.
- Original Article;
- Article is from March 18, 2025;
- I personally don’t reccomend following sciencedaily as they seem to have bad practices like publishing old articles frequently.
Devil weed, everyone involved should be killed and the research burned.
Publically. Bonfire style. In the middle of city square.
Instructions unclear, now someone’s hosting an execution-themed costume party downtown while blasting Childish Gambino Bonfire mashups
I’m… actually OK with this
Dunno. Sounds they were clear enough
That’s why they are finding out about this now and not 1950. Witch hunts are so great, everyone benefits (not).
Gettingbhigh is very important to me, and I stand by my statement.
Booooringg.
I love as this news spread, all the “but i need it for my pain/depression/etc/etc!, its the only thing that helps!” types are now just straight up basically saying they don’t give a fuck about anything it does but the high.
I knew this was gonna happen.
Just like I know the type of responses I’m gonna get from the outed potheads and addicts.
Potheads and addicts? Holy shit, is it still 1990 and you’ve got some weird fucking prejudice against how other people choose to spend their time or how they medicate themselves? Oh boy…
Just like I know the type of responses I’m gonna get
You invite the circus when you put the clown mask on.
Potheads and addicts? Holy shit, is it still 1990 and you’ve got some weird fucking prejudice against how other people choose to spend their time or how they medicate themselves? Oh boy…
I dont care what you do in your own home.
But potheads, like vegans, cant just contain it to their own home and shut up about it. They gotta make sure everyone, everywhere, in every fucking conversation, knows about what they do.
And for the longest time, they all tried to hide behind pot being the magical medicine that cured all woes, and now we have science actually isolating beneficial components without hte high, and the overwhelming response is “NO, I DONT WANT THE BENEFICIAL EFFECTS, I WANT THE HIGH”, which is exactly what addicts would say.
You are the one who brought up vegens in a conversation about pot. But sure, keep telling that yourself.
Sure buddy.
You are shadowboxing lol. I see orders of magnitude more people complaining about vegans with little to no prompting than I see any vegans saying they are vegan.
What kind of naïve person makes grandiose claims of others, while also unfairly aggregating them to the grouping of your own subjective, unflattering, and inaccurate images of them? You’re basically inventing these people, potheads and vegan, to make a dumb point about how some people like to talk about their personal choices a lot. Whoopty doo, you dweeb.
You know what’s funny? Aside from the fact that I’m mentioning it now, I consume a grotesque volume of cannabis. Truly grotesque, I promise more than whatever you’re thinking. I don’t bring it up, though, ever. Why? Because I’m an actual human being, as opposed to whatever fantasy you’ve got going on up there.
And for the longest time, they all tried to hide behind pot being the magical medicine that cured all woes, and now we have science actually isolating beneficial components without hte high, and the overwhelming response is “NO, I DONT WANT THE BENEFICIAL EFFECTS, I WANT THE HIGH”, which is exactly what addicts would say.
No it’s not. Please, for the love of god, do good research and get that stuff. That’s great for children, people who don’t want to be high, and people who can’t be high (e.g., on the clock) but still need the medicine.
I still want to get high, though. There’s nothing wrong with that. The issue is with you, if you have a problem with that.
sure buddy.
Well, at least your username checks out…
Sure buddy.
Wow…
I bet you’re a riot at parties, huh.
If you’re going to go for the personal attack, could you at least be entertaining with it? This is something a 14 year old would regurgitate 30 years ago.
Oh sorry, I thought I’d try for something a moron would understand. I didn’t want to use too many big words and confuse you.
Next time try lowering the bar to something a moron can actually produce instead of worrying about other people 👍
So you want me to reduce my not-so-complex insult to something a moron would produce so you can think you’re winning an arguing with a moron?
Fuck, you’re smart hey.
Never met someone smoking weed who acts like a militant vegan about it.
Rage bait.
If I’m in chronic pain then I’m going to want to be high too. Nothing wrong with being high in your own house.
-I don’t even like weed. The high just feels like taking benedryl to me.
It would be better to have both as an option.
Yeah… Maybe they like getting high too. What’s the problem? The only issue I see with cannabis is that people smoke it.
There are tons of issues with cannabis. It severely diminishes your ability to solve problems or concentrate on complex tasks over a period of time. I’m not in favor of people casually being drunk every day, and therefore I am not in favor of people casually smoking weed every day.
If we want people to be able to get the medical benefits of cannabinoids, like anti-emetics, pain relief, appetite, anti-psychotics et.c. we need to research their mechanism of action and synergy between each other. People who are sick do not necessarily also want to be high, especially if you have to take your medication over an extended period of time.
So cannabis and alcohol bad, caffeine fine?
Caffeine and nicotine are problematic for various reasons, but they are not significantly mind-altering. Because of that, chronic use of caffeine and nicotine is not problematic with regard to being able to perform most tasks.
but they are not significantly mind-altering.
Used one without the high. Worked beautifully. Too expensive in the long run. But really appreciated it. Dont want the high at all. It had no side effects. Just gentle pain relief. Bliss.
@Timonesaysno I love the high from cannabis, but that doesn’t mean that I want it necessarily in all situations. Like for instance, on Friday night I randomly got nauseous, and the only thing I had was my THC vape. Well, I didn’t care, because we were having fun anyway, I may not have been able to get away with that is easily outside of a chill situation, such as a softball game, which is where I was last night.
:(
And then it gets patented and costs $10,000 a dose.
Currently happening with kratom and psylocibin as well.
Yeah, the most legit meds come from a gas station.
I don’t think you know what you’re talking about. There are multiple patents pending on modified kratom alkaloids.
https://en.wikipedia.org/wiki/Deuterated_mitragynine?wprov=sfla1
I’ve read about others but that was the first one I came across in development.
Psilocin pro-drugs are another category with multiple patents pending, Mindset Pharma holding a few.
https://en.wikipedia.org/wiki/MSP-1014?wprov=sfla1
Here is another patented by Reunion Neuroscience.
Lol. Where’s the fun then haha? /s
Reduces pain in mouse models?
It’s a nice way of saying:
We gave mice _____ to see if we could cure them of ____!
https://pmc.ncbi.nlm.nih.gov/articles/PMC8621025/
Explains it more in depth:
Understanding and treating human diseases requires thorough knowledge of disease-causing molecular and pathophysiological mechanisms. Despite the recent advances in induced pluripotent stem cell techniques, many of these aspects remain challenging to study, especially under physiological conditions in patient-derived material [1,2]. In order to be reliable and valuable, the disease model should recapitulate if not the entire human disease phenotype, then at least the key features of each specific disease under study [3]. For precision medicine, a good understanding of the genetic bases of variation in phenotypes and their interaction with the environment in health and disease are required [4,5]. Thus, animal models, and especially genetically modified (GM) mice, offer great potential to serve as precious preclinical models that facilitate basic understanding of disease pathomechanisms and provide clues for the development of treatment options and novel strategies to follow a treatment’s response.
I’m going to run with a little cynicism.
I live somewhere where cannabis is not legal. There’s pressure, sure, but there’s resistance too.
One of the factors that helped it legalized in western countries like Canada and the US is the notion of health. Pain relief. Treatment for some chronic illnesses.
That’s cool. But imagine a pharmaceutical company isolates those health things.
No need to legalized cannabis anymore.
This stuff supports the anti-lefalisation movement by taking the benefits from it.
Damned if we want to use if recreationally.
What do you think happened to cocaine and heroine? Hell, alcohol some places.
What happened to them? I really don’t know the history behind these hard drugs.
They started as medicines and were concentrated, distilled, and extracted to the point where the medicine it became was deadlier than the cure it provided.
Coca leaves are still consumed medicinally/recreationally in some parts of south america.
Poppy seeds have a whole history of being abused and weaponized through the silk road.
Marijuana has faced a similar story, though without the deaths. This hasn’t stopped governments around the world from conflating the deaths caused by other things with the use of medicines that in no way cause death.
I have to point out that in medicine we use the derivatives from cocaine, novacaine, lidocaine, benzocaine etc as potent short/medium term anaesthetics. Drugs like these make dental extractions for example relatively painless today. Pure cocaine was used previously but was far more toxic to the liver and had a much higher incidence of allergic reaction than its modern derivatives.
This is so stupid. Just more pointless research to make you look the wrong way. Like Cannabis is this miracle plant that could offer us things we didn’t have access to before.
I love Cannabis, she has been one of my best friends for over 25 years but let’s not kid ourselves. These terpenes aren’t unique to Cannabis, you shouldn’t be getting them from Cannabis, you should be getting them from your food.
Unfortunately the food you are sold is dead and empty. Not only are processed foods stripped of all you actually need to support a healthy body, the fruits and veggies you buy are mostly dead strains that are grown in dead soil. It’s cheaper upfront, but then you have to pay for it in supplements, taxes and hospital bills.
Geraniol: Citronella, rose, lemongrass
Linalool: Lavender, mints, citrus, coriander, basil
Beta-caryophyllene: Black pepper, rosemary, cloves, hops
Alpha-humulene: Sage, hops, ginseng, ginger, mints
Terpenes are the key. Spice up your lives.
Slam it to the left if you’re havin’ a good time, shake it to the right If ya know that you feel fine
Chicas to the front! Ha! Ha!
Because you’re not allowed to feel good with any medical treatment.
No.
Maybe you want to drive a car safely.
Then I use paracetamol and codeine, and stay off medicinal cannabis
Ok thats not exactly an improvement.
i am sure this cannabis is safer than paracetamol or codeine. and there are people who want that
codeine is an opiate. you’re not allowed to drive on that.
let me literally tell you what my pain management MD told me. “Practice doing the sobriety tests on opioids until you can pass” i think i had the worst doctor.
was his last name zuckerkorn?
i wish i was joking
I am here
I take one tablet, if I need to
“Take opioids instead of non-psychoactive cannabinoids for pain” is a wild take my guy
There was an injection of tongue in cheek with the first comment as well, but that seemed to have missed most
There’s a big difference between one Panadeine forte and the opioids you might be thinking of. Sometimes it’s just a paracetamol
…paracetamol is not an opioid.
I once had a social worker tell me I should stop smoking weed and get on opiates. I told him he could go fuck himself.
In UK you can if it doesn’t affect your driving.
and how do you tell if it has? imagine if the standard for alcohol was the same…
If you can drive safely then go ahead but if you’re impaired by too much of anything that you would drive poorly then don’t. I thought this was common sense.
the uk sticks out in the statistics of legal limits for alcohol in europe at 0.8‰ BAC; most countries are at 0.2 with some having a zero-tolerance policy, because it affects people so differently and it’s hard to tell.
Codeine can still make people sleepy and sluggish. It’s still an opioid that can lead to dependence and withdrawal. It still has negative GI side effects causing constipation. It’s not a good idea for driving while under the influence. If this can help people in pain without side effect that can cause impairment, why not. Getting high off of cannabis can still be allowed.
I’m not going to argue, really
I take one if I have to drive and I’m in pain.
But if you have cannabis without the high, you could use that instead and be safer.
I’d love to have the option as a medical marijuana user. Not as punishment for having pain, but for having more options.
Yeah look, I don’t it’s a bad thing at all, I know this would benefit many people
Your parent comment resonated with me, I get that knee jerk reaction about punishing pain. But yeah I can begrudgingly admit that I would use this if it was available for driving and such.
You don’t need to argue. You just need to accept that every time you do that you put your life, and the lives of the people around you, in danger. And that’s simply a fact.
My friend, in the UK you can literally buy Panadol both with and without codiene over the counter at a pharmacy
They have said multiple times they use the without for the most part, which is just paracetamol (acetaminophen).
The UK and elsewhere don’t have the same problem with opiates as the US does.
It’s not an offense to drive on medications unless it impares you, in effect giving the police reason to stop you from driving if impaired by it and legal means to prosecute you if you cause harm due to the imparement.
That also means I could drive whilst high from my cannabis prescription if there was no imparement.
Yeah look I think there might be a difference between one Panadeine forte and hard core opiates that have people nodding off.
Certainly, it’s a lot better than vaping two caps before driving and nine times out of ten it’s just a paracetamol anyway
the first time i took Hydrocodone was after I had my wisdom teeth pulled. I slept a full 8 hours, got up, took my next dose, and then proceeded to pass out for ANOTHER full 8 hours. I put two and two together pretty quickly and just decided to deal with the pain.
Or because plenty of people want medicine without unwanted side effects.
Yah the mental haze isn’t a fun trap to fall into. (young me as source)
On one hand, it sounds like Puritanical bullshit, but on the other hand, I’d like the option.
Idk some people like going to work without pain.
For me cannabis is an incredibly strong depressant. I can feel suicidal for free with pain, thanks.
Yall are fuckin wierd lol. I absolutely love cannabis, both recreationally and medically. But if there’s an additional choice to isolate the pain relief aspect without the psychoactive effects of THC, that would be amazing as well. It’s not an either/or choice - there are absolutely use cases for both. Regardless, I’m pretty skeptical that terpenes are any more useful for pain control than essential oils are.
Thing is, this is strain that’s gonna be legalized if any. So any fun use would still be illegal.
The states in the US that have already legalized weed are not going to let go of that tax revenue anytime soon.
This industry relies on innuendo and bots to fill comments on Reddit, anything but actual clinical trials with placebo controls. Same thing with terpene sleep aids.
If I’m not wrong, essential oils are rich in terpenes and maybe that’s what makes them useful as a pain treatment.
Essential oils are not useful as pain treatment.
I have friends that use them and disagree.
You have friends that have made a therapeutic ritual out of using essential oils which helps them only because the placebo effect can be very powerful for pain. Literally anything could stand in for the essential oils. Swap their oil vials out with convincing fakes and they’ll never know the difference because it’s the ritual of smelling and/or applying the oils that’s helping them, not any real physical mechanism of the compounds in the oils interacting with their biology.
Fuck that.
